Global investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease
Identifieur interne : 000B99 ( Main/Exploration ); précédent : 000B98; suivant : 000C00Global investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease
Auteurs : Jessie Theuns [Belgique] ; Aline Verstraeten [Belgique] ; Kristel Sleegers [Belgique] ; Eline Wauters [Belgique] ; Ilse Gijselinck [Belgique] ; Stefanie Smolders [Belgique] ; David Crosiers [Belgique] ; Ellen Corsmit [Belgique] ; Ellen Elinck [Belgique] ; Manu Sharma [Allemagne] ; Rejko Krüger [Allemagne] ; Suzanne Lesage [France] ; Alexis Brice [France] ; SUN JU CHUNG [Corée du Sud] ; Mi-Jung Kim [Corée du Sud] ; YOUNG JIN KIM [Corée du Sud] ; Owen A. Ross [États-Unis] ; Zbigniew K. Wszolek [États-Unis] ; Ekaterina Rogaeva [Canada] ; ZHENGRUI XI [Canada] ; Anthony E. Lang [Canada] ; Christine Klein [Allemagne] ; Anne Weissbach [Allemagne] ; George D. Mellick ; Peter A. Silburn [Australie] ; Georgios M. Hadjigeorgiou [Australie] ; Efthimios Dardiotis [Grèce] ; Nobutaka Hattori [Japon] ; Kotaro Ogaki [Japon] ; Eng-King Tan [Singapour] ; YI ZHAO [Singapour] ; Jan Aasly [Norvège] ; Enza Maria Valente [Italie] ; Simona Petrucci [Italie] ; Grazia Annesi ; Aldo Quattrone ; Carlo Ferrarese ; Laura Brighina ; Angela Deutschl Nder ; Andreas Puschmann ; Christer Nilsson ; Gaëtan Garraux ; Mark S. Le Doux ; Ronald F. Pfeiffer ; Magdalena Boczarska-Jedynak ; Grzegorz Opala ; Demetrius M. Maraganore ; Sebastian Engelborghs [Belgique] ; Peter Paul De Deyn [Belgique, Pays-Bas] ; Patrick Cras ; Marc Cruts [Belgique] ; Christine Van Broeckhoven [Belgique]Source :
- Neurology [ 0028-3878 ] ; 2014.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Objectives: The objective of this study is to clarify the role of (G4C2)n expansions in the etiology of Parkinson disease (PD) in the worldwide multicenter Genetic Epidemiology of Parkinson's Disease (GEO-PD) cohort. Methods: C9orf72 (G4C2)n repeats were assessed in a GEO-PD cohort of 7,494 patients diagnosed with PD and 5,886 neurologically healthy control individuals ascertained in Europe, Asia, North America, and Australia. Results: A pathogenic (G4C2)n>60 expansion was detected in only 4 patients with PD (4/7,232; 0.055%), all with a positive family history of neurodegenerative dementia, amyotrophic lateral sclerosis, or atypical parkinsonism, while no carriers were detected with typical sporadic or familial PD. Meta-analysis revealed a small increase in risk of PD with an increasing number of (G4C2)n repeats; however, we could not detect a robust association between the C9orf72 (G4C2)n repeat and PD, and the population attributable risk was low. Conclusions: Together, these findings indicate that expansions in C9orf72 do not have a major role in the pathogenesis of PD. Testing for C9orf72 repeat expansions should only be considered in patients with PD who have overt symptoms of frontotemporal lobar degeneration/amyotrophic lateral sclerosis or apparent family history of neurodegenerative dementia or motor neuron disease.
Affiliations:
- Allemagne, Australie, Belgique, Canada, Corée du Sud, France, Grèce, Italie, Japon, Norvège, Pays-Bas, Singapour, États-Unis
- Bade-Wurtemberg, District de Tübingen, Ontario, Province d'Anvers, Région flamande, Trøndelag, Île-de-France
- Anvers, Paris, Séoul, Tokyo, Toronto, Trondheim, Tübingen
- Université d'Anvers, Université de Toronto
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Hospital</s1><s2>Edegem</s2><s3>BEL</s3><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Edegem</wicri:noRegion></affiliation></author><author><name sortKey="Corsmit, Ellen" sort="Corsmit, Ellen" uniqKey="Corsmit E" first="Ellen" last="Corsmit">Ellen Corsmit</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute Born-Bunge, University of Antwerp</s1><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName><orgName type="university">Université d'Anvers</orgName></affiliation></author><author><name sortKey="Elinck, Ellen" sort="Elinck, Ellen" uniqKey="Elinck E" first="Ellen" last="Elinck">Ellen Elinck</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute Born-Bunge, University of Antwerp</s1><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName><orgName type="university">Université d'Anvers</orgName></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and DZNE-German Center for Neurodegenerative Diseases</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Institute for Clinical Epidemiology and Applied Biometry, University of Tuebingen</s1><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Institute for Clinical Epidemiology and Applied Biometry, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and DZNE-German Center for Neurodegenerative Diseases</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, UMR_S975, Université Pierre et Marie Curie-Paris, CNRS, UMR 7225, AP-HP, Pitié-Salpêtrière Hospital</s1><s3>FRA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pitié-Salpêtrière Hospital</wicri:noRegion><wicri:noRegion>INSERM, UMR_S975, Université Pierre et Marie Curie-Paris, CNRS, UMR 7225, AP-HP, Pitié-Salpêtrière Hospital</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, UMR_S975, Université Pierre et Marie Curie-Paris, CNRS, UMR 7225, AP-HP, Pitié-Salpêtrière Hospital</s1><s3>FRA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pitié-Salpêtrière Hospital</wicri:noRegion><wicri:noRegion>INSERM, UMR_S975, Université Pierre et Marie Curie-Paris, CNRS, UMR 7225, AP-HP, Pitié-Salpêtrière Hospital</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>AP-HP, Pitiê-Salpêtrière Hospital, Department of Genetics and Cytogenetics</s1><s2>Paris</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sun Ju Chung" sort="Sun Ju Chung" uniqKey="Sun Ju Chung" last="Sun Ju Chung">SUN JU CHUNG</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology , Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Mi Jung" sort="Kim, Mi Jung" uniqKey="Kim M" first="Mi-Jung" last="Kim">Mi-Jung Kim</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology , Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Young Jin Kim" sort="Young Jin Kim" uniqKey="Young Jin Kim" last="Young Jin Kim">YOUNG JIN KIM</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology , Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neuroscience, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Tanz Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto</s1><s3>CAN</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Zhengrui Xi" sort="Zhengrui Xi" uniqKey="Zhengrui Xi" last="Zhengrui Xi">ZHENGRUI XI</name><affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Tanz Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto</s1><s3>CAN</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Toronto Western Hospital Research Institute, University Health Network</s1><s2>Toronto</s2><s3>CAN</s3><sZ>21 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Institute of Neurogenetics, University of Luebeck</s1><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>Institute of Neurogenetics, University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Weissbach, Anne" sort="Weissbach, Anne" uniqKey="Weissbach A" first="Anne" last="Weissbach">Anne Weissbach</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Institute of Neurogenetics, University of Luebeck</s1><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>Institute of Neurogenetics, University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>University of Queensland, Centre for Clinical Research</s1><s2>Queensland</s2><s3>AUS</s3><sZ>25 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Eskitis Institute for Drug Discovery, Griffith University</s1><s2>Queensland</s2><s3>AUS</s3><sZ>26 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Dardiotis, Efthimios" sort="Dardiotis, Efthimios" uniqKey="Dardiotis E" first="Efthimios" last="Dardiotis">Efthimios Dardiotis</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Neurology, Neuroscience Unit, Faculty of Medicine, School of Health Sciences, University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>27 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Neurology, Juntendo University School of Medicine</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Ogaki, Kotaro" sort="Ogaki, Kotaro" uniqKey="Ogaki K" first="Kotaro" last="Ogaki">Kotaro Ogaki</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Neurology, Juntendo University School of Medicine</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Department of Neurology, Singapore General Hospital, National Neuroscience Institute</s1><s3>SGP</s3><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Singapour</country><wicri:noRegion>Department of Neurology, Singapore General Hospital, National Neuroscience Institute</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Duke NUS Graduate Medical School</s1><s3>SGP</s3><sZ>30 aut.</sZ></inist:fA14><country>Singapour</country><wicri:noRegion>Duke NUS Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Yi Zhao" sort="Yi Zhao" uniqKey="Yi Zhao" last="Yi Zhao">YI ZHAO</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Department of Neurology, Singapore General Hospital, National Neuroscience Institute</s1><s3>SGP</s3><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Singapour</country><wicri:noRegion>Department of Neurology, Singapore General Hospital, National Neuroscience Institute</wicri:noRegion></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="3"><inist:fA14 i1="23"><s1>Department of Neurology, St. Olav's Hospital</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>32 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Department of Neuroscience, Norwegian University of Science and Technology (NTNU)</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>32 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>IRCCS Casa Sollievo della Sofferenza Hospital, Mendel Laboratory</s1><s2>San Giovanni Rotondo</s2><s3>ITA</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Petrucci, Simona" sort="Petrucci, Simona" uniqKey="Petrucci S" first="Simona" last="Petrucci">Simona Petrucci</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>IRCCS Casa Sollievo della Sofferenza Hospital, Mendel Laboratory</s1><s2>San Giovanni Rotondo</s2><s3>ITA</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name></author><author><name sortKey="Deutschl Nder, Angela" sort="Deutschl Nder, Angela" uniqKey="Deutschl Nder A" first="Angela" last="Deutschl Nder">Angela Deutschl Nder</name></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name></author><author><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaëtan" last="Garraux">Gaëtan Garraux</name></author><author><name sortKey="Le Doux, Mark S" sort="Le Doux, Mark S" uniqKey="Le Doux M" first="Mark S." last="Le Doux">Mark S. Le Doux</name></author><author><name sortKey="Pfeiffer, Ronald F" sort="Pfeiffer, Ronald F" uniqKey="Pfeiffer R" first="Ronald F." last="Pfeiffer">Ronald F. Pfeiffer</name></author><author><name sortKey="Boczarska Jedynak, Magdalena" sort="Boczarska Jedynak, Magdalena" uniqKey="Boczarska Jedynak M" first="Magdalena" last="Boczarska-Jedynak">Magdalena Boczarska-Jedynak</name></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name></author><author><name sortKey="Engelborghs, Sebastian" sort="Engelborghs, Sebastian" uniqKey="Engelborghs S" first="Sebastian" last="Engelborghs">Sebastian Engelborghs</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology and Memory Clinic , Hospital Network Antwerp, Middelheim and Hoge Beuken</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>48 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="De Deyn, Peter Paul" sort="De Deyn, Peter Paul" uniqKey="De Deyn P" first="Peter Paul" last="De Deyn">Peter Paul De Deyn</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology and Memory Clinic , Hospital Network Antwerp, Middelheim and Hoge Beuken</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>48 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology and Alzheimer Research Center, Universiry of Groningen and University Medical Center Groningen</s1><s3>NLD</s3><sZ>49 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Neurology and Alzheimer Research Center, Universiry of Groningen and University Medical Center Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Cras, Patrick" sort="Cras, Patrick" uniqKey="Cras P" first="Patrick" last="Cras">Patrick Cras</name></author><author><name sortKey="Cruts, Marc" sort="Cruts, Marc" uniqKey="Cruts M" first="Marc" last="Cruts">Marc Cruts</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">15-0006093</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 15-0006093 INIST</idno><idno type="RBID">Pascal:15-0006093</idno><idno type="wicri:Area/PascalFrancis/Corpus">000003</idno><idno type="wicri:Area/PascalFrancis/Curation">000C13</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000019</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000019</idno><idno type="wicri:doubleKey">0028-3878:2014:Theuns J:global:investigation:and</idno><idno type="wicri:Area/Main/Merge">000C04</idno><idno type="wicri:Area/Main/Curation">000B99</idno><idno type="wicri:Area/Main/Exploration">000B99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Global investigation and meta-analysis of the C9orf72 (G<sub>4</sub>C<sub>2</sub>)<sub>n</sub> repeat in Parkinson disease</title><author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute Born-Bunge, University of Antwerp</s1><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName><orgName type="university">Université d'Anvers</orgName></affiliation></author><author><name sortKey="Verstraeten, Aline" sort="Verstraeten, Aline" uniqKey="Verstraeten A" first="Aline" last="Verstraeten">Aline Verstraeten</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute Born-Bunge, University of Antwerp</s1><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName><orgName type="university">Université d'Anvers</orgName></affiliation></author><author><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute Born-Bunge, University of Antwerp</s1><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName><orgName type="university">Université d'Anvers</orgName></affiliation></author><author><name sortKey="Wauters, Eline" sort="Wauters, Eline" uniqKey="Wauters E" first="Eline" last="Wauters">Eline Wauters</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute Born-Bunge, University of Antwerp</s1><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName><orgName type="university">Université d'Anvers</orgName></affiliation></author><author><name sortKey="Gijselinck, Ilse" sort="Gijselinck, Ilse" uniqKey="Gijselinck I" first="Ilse" last="Gijselinck">Ilse Gijselinck</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute Born-Bunge, University of Antwerp</s1><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName><orgName type="university">Université d'Anvers</orgName></affiliation></author><author><name sortKey="Smolders, Stefanie" sort="Smolders, Stefanie" uniqKey="Smolders S" first="Stefanie" last="Smolders">Stefanie Smolders</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute Born-Bunge, University of Antwerp</s1><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName><orgName type="university">Université d'Anvers</orgName></affiliation></author><author><name sortKey="Crosiers, David" sort="Crosiers, David" uniqKey="Crosiers D" first="David" last="Crosiers">David Crosiers</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute Born-Bunge, University of Antwerp</s1><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName><orgName type="university">Université d'Anvers</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Antwerp University Hospital</s1><s2>Edegem</s2><s3>BEL</s3><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Edegem</wicri:noRegion></affiliation></author><author><name sortKey="Corsmit, Ellen" sort="Corsmit, Ellen" uniqKey="Corsmit E" first="Ellen" last="Corsmit">Ellen Corsmit</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute Born-Bunge, University of Antwerp</s1><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName><orgName type="university">Université d'Anvers</orgName></affiliation></author><author><name sortKey="Elinck, Ellen" sort="Elinck, Ellen" uniqKey="Elinck E" first="Ellen" last="Elinck">Ellen Elinck</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Institute Born-Bunge, University of Antwerp</s1><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName><orgName type="university">Université d'Anvers</orgName></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and DZNE-German Center for Neurodegenerative Diseases</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Institute for Clinical Epidemiology and Applied Biometry, University of Tuebingen</s1><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>Institute for Clinical Epidemiology and Applied Biometry, University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and DZNE-German Center for Neurodegenerative Diseases</s1><s2>Tuebingen</s2><s3>DEU</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, UMR_S975, Université Pierre et Marie Curie-Paris, CNRS, UMR 7225, AP-HP, Pitié-Salpêtrière Hospital</s1><s3>FRA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pitié-Salpêtrière Hospital</wicri:noRegion><wicri:noRegion>INSERM, UMR_S975, Université Pierre et Marie Curie-Paris, CNRS, UMR 7225, AP-HP, Pitié-Salpêtrière Hospital</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, UMR_S975, Université Pierre et Marie Curie-Paris, CNRS, UMR 7225, AP-HP, Pitié-Salpêtrière Hospital</s1><s3>FRA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Pitié-Salpêtrière Hospital</wicri:noRegion><wicri:noRegion>INSERM, UMR_S975, Université Pierre et Marie Curie-Paris, CNRS, UMR 7225, AP-HP, Pitié-Salpêtrière Hospital</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>CNRS, UMR 7225</s1><s2>Paris</s2><s3>FRA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>AP-HP, Pitiê-Salpêtrière Hospital, Department of Genetics and Cytogenetics</s1><s2>Paris</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sun Ju Chung" sort="Sun Ju Chung" uniqKey="Sun Ju Chung" last="Sun Ju Chung">SUN JU CHUNG</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology , Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Mi Jung" sort="Kim, Mi Jung" uniqKey="Kim M" first="Mi-Jung" last="Kim">Mi-Jung Kim</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology , Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Young Jin Kim" sort="Young Jin Kim" uniqKey="Young Jin Kim" last="Young Jin Kim">YOUNG JIN KIM</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology , Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Neuroscience, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Tanz Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto</s1><s3>CAN</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Zhengrui Xi" sort="Zhengrui Xi" uniqKey="Zhengrui Xi" last="Zhengrui Xi">ZHENGRUI XI</name><affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Tanz Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto</s1><s3>CAN</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Toronto Western Hospital Research Institute, University Health Network</s1><s2>Toronto</s2><s3>CAN</s3><sZ>21 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Institute of Neurogenetics, University of Luebeck</s1><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>Institute of Neurogenetics, University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Weissbach, Anne" sort="Weissbach, Anne" uniqKey="Weissbach A" first="Anne" last="Weissbach">Anne Weissbach</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Institute of Neurogenetics, University of Luebeck</s1><s3>DEU</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>Institute of Neurogenetics, University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>University of Queensland, Centre for Clinical Research</s1><s2>Queensland</s2><s3>AUS</s3><sZ>25 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Eskitis Institute for Drug Discovery, Griffith University</s1><s2>Queensland</s2><s3>AUS</s3><sZ>26 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Dardiotis, Efthimios" sort="Dardiotis, Efthimios" uniqKey="Dardiotis E" first="Efthimios" last="Dardiotis">Efthimios Dardiotis</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Neurology, Neuroscience Unit, Faculty of Medicine, School of Health Sciences, University of Thessaly</s1><s2>Larissa</s2><s3>GRC</s3><sZ>27 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Neurology, Juntendo University School of Medicine</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Ogaki, Kotaro" sort="Ogaki, Kotaro" uniqKey="Ogaki K" first="Kotaro" last="Ogaki">Kotaro Ogaki</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Neurology, Juntendo University School of Medicine</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Department of Neurology, Singapore General Hospital, National Neuroscience Institute</s1><s3>SGP</s3><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Singapour</country><wicri:noRegion>Department of Neurology, Singapore General Hospital, National Neuroscience Institute</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Duke NUS Graduate Medical School</s1><s3>SGP</s3><sZ>30 aut.</sZ></inist:fA14><country>Singapour</country><wicri:noRegion>Duke NUS Graduate Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Yi Zhao" sort="Yi Zhao" uniqKey="Yi Zhao" last="Yi Zhao">YI ZHAO</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Department of Neurology, Singapore General Hospital, National Neuroscience Institute</s1><s3>SGP</s3><sZ>30 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Singapour</country><wicri:noRegion>Department of Neurology, Singapore General Hospital, National Neuroscience Institute</wicri:noRegion></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="3"><inist:fA14 i1="23"><s1>Department of Neurology, St. Olav's Hospital</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>32 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Department of Neuroscience, Norwegian University of Science and Technology (NTNU)</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>32 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>IRCCS Casa Sollievo della Sofferenza Hospital, Mendel Laboratory</s1><s2>San Giovanni Rotondo</s2><s3>ITA</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Petrucci, Simona" sort="Petrucci, Simona" uniqKey="Petrucci S" first="Simona" last="Petrucci">Simona Petrucci</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>IRCCS Casa Sollievo della Sofferenza Hospital, Mendel Laboratory</s1><s2>San Giovanni Rotondo</s2><s3>ITA</s3><sZ>33 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name></author><author><name sortKey="Deutschl Nder, Angela" sort="Deutschl Nder, Angela" uniqKey="Deutschl Nder A" first="Angela" last="Deutschl Nder">Angela Deutschl Nder</name></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name></author><author><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaëtan" last="Garraux">Gaëtan Garraux</name></author><author><name sortKey="Le Doux, Mark S" sort="Le Doux, Mark S" uniqKey="Le Doux M" first="Mark S." last="Le Doux">Mark S. Le Doux</name></author><author><name sortKey="Pfeiffer, Ronald F" sort="Pfeiffer, Ronald F" uniqKey="Pfeiffer R" first="Ronald F." last="Pfeiffer">Ronald F. Pfeiffer</name></author><author><name sortKey="Boczarska Jedynak, Magdalena" sort="Boczarska Jedynak, Magdalena" uniqKey="Boczarska Jedynak M" first="Magdalena" last="Boczarska-Jedynak">Magdalena Boczarska-Jedynak</name></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name></author><author><name sortKey="Engelborghs, Sebastian" sort="Engelborghs, Sebastian" uniqKey="Engelborghs S" first="Sebastian" last="Engelborghs">Sebastian Engelborghs</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology and Memory Clinic , Hospital Network Antwerp, Middelheim and Hoge Beuken</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>48 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="De Deyn, Peter Paul" sort="De Deyn, Peter Paul" uniqKey="De Deyn P" first="Peter Paul" last="De Deyn">Peter Paul De Deyn</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology and Memory Clinic , Hospital Network Antwerp, Middelheim and Hoge Beuken</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>48 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology and Alzheimer Research Center, Universiry of Groningen and University Medical Center Groningen</s1><s3>NLD</s3><sZ>49 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Neurology and Alzheimer Research Center, Universiry of Groningen and University Medical Center Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Cras, Patrick" sort="Cras, Patrick" uniqKey="Cras P" first="Patrick" last="Cras">Patrick Cras</name></author><author><name sortKey="Cruts, Marc" sort="Cruts, Marc" uniqKey="Cruts M" first="Marc" last="Cruts">Marc Cruts</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Brain Diseases Group , Department of Molecular Genetics, VIB</s1><s2>Antwerp</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>51 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: The objective of this study is to clarify the role of (G<sub>4</sub>C<sub>2</sub>)<sub>n</sub> expansions in the etiology of Parkinson disease (PD) in the worldwide multicenter Genetic Epidemiology of Parkinson's Disease (GEO-PD) cohort. Methods: C9orf72 (G<sub>4</sub>C<sub>2</sub>)<sub>n</sub> repeats were assessed in a GEO-PD cohort of 7,494 patients diagnosed with PD and 5,886 neurologically healthy control individuals ascertained in Europe, Asia, North America, and Australia. Results: A pathogenic (G<sub>4</sub>C<sub>2</sub>)<sub>n>60</sub> expansion was detected in only 4 patients with PD (4/7,232; 0.055%), all with a positive family history of neurodegenerative dementia, amyotrophic lateral sclerosis, or atypical parkinsonism, while no carriers were detected with typical sporadic or familial PD. Meta-analysis revealed a small increase in risk of PD with an increasing number of (G<sub>4</sub>C<sub>2</sub>)<sub>n</sub> repeats; however, we could not detect a robust association between the C9orf72 (G<sub>4</sub>C<sub>2</sub>)<sub>n</sub> repeat and PD, and the population attributable risk was low. Conclusions: Together, these findings indicate that expansions in C9orf72 do not have a major role in the pathogenesis of PD. Testing for C9orf72 repeat expansions should only be considered in patients with PD who have overt symptoms of frontotemporal lobar degeneration/amyotrophic lateral sclerosis or apparent family history of neurodegenerative dementia or motor neuron disease.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Corée du Sud</li><li>France</li><li>Grèce</li><li>Italie</li><li>Japon</li><li>Norvège</li><li>Pays-Bas</li><li>Singapour</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>Ontario</li><li>Province d'Anvers</li><li>Région flamande</li><li>Trøndelag</li><li>Île-de-France</li></region><settlement><li>Anvers</li><li>Paris</li><li>Séoul</li><li>Tokyo</li><li>Toronto</li><li>Trondheim</li><li>Tübingen</li></settlement><orgName><li>Université d'Anvers</li><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><name sortKey="Boczarska Jedynak, Magdalena" sort="Boczarska Jedynak, Magdalena" uniqKey="Boczarska Jedynak M" first="Magdalena" last="Boczarska-Jedynak">Magdalena Boczarska-Jedynak</name><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><name sortKey="Cras, Patrick" sort="Cras, Patrick" uniqKey="Cras P" first="Patrick" last="Cras">Patrick Cras</name><name sortKey="Deutschl Nder, Angela" sort="Deutschl Nder, Angela" uniqKey="Deutschl Nder A" first="Angela" last="Deutschl Nder">Angela Deutschl Nder</name><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaëtan" last="Garraux">Gaëtan Garraux</name><name sortKey="Le Doux, Mark S" sort="Le Doux, Mark S" uniqKey="Le Doux M" first="Mark S." last="Le Doux">Mark S. Le Doux</name><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><name sortKey="Pfeiffer, Ronald F" sort="Pfeiffer, Ronald F" uniqKey="Pfeiffer R" first="Ronald F." last="Pfeiffer">Ronald F. 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